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EXCRETION.Is the removal of waste substances from the body, which are produced by the cells activity (metabolism) and substances of which the body has an excess. Waste substances are usually harmful to the living body. So the body separate, detoxicate, and remove them.             There are many chemical reactions in the organism. All these reactions give rise to the end products, some of which are poisonous or could affect the normal chemical reactions in the body if they were allowed to accumulate.
i. Digested substances which is in excess and can not be stored in the body are removed from the body together with useless and poisonous by products of metabolism by the process called excretion..
ii. All these reactions are useful to the body;eg –some produce energy (respiration).
--Some build new body tissues.
--Some produce useful chemicals, ie. enzymes and hormones
iii But yet, some of these reactions give rise to by products which are useless or even harmful to the body. These are called excretory products and are removed from the body by excretory organs, ie. kidney, lungs, skin, and liver
Excretory Products.                                              
1.Carbon dioxide is useless in the body but it can also be harmful if allowed to accumulate in large quantities, ie. forming carbonic acid which can damage body cells.
-So carbon dioxide is an excretory product and is removed by the lungs.
2.Waternormally it is useful to the body but it can be harmful if allowed to accumulate to the point that it dilutes the blood and tissue fluid. So it has to be removed as an excretory product.
Metabolism; some of the by-products of metabolism though useless when they are produced, they are not excreted because they can be turned into useful materials. Example lactic acid formed in the muscles of vertebrates during vigorous exercises.
3..Lactic acid is useless until converted back into glucose where it is used in respiration or stored as glycogen.
 The most poisonous by product of metabolism is ammonia. It is formed during breakdown of excess amino acid in the liver. Ammonia is very soluble and kills the cells if its concentration rises above 1 part in 25,000. Liver converts ammonia into urea (relatively harmless) which is released into the blood. Kidney extracts it from the blood and excretes as a part of urine.
Other examples are hormones, cholesterol (fats), bilirubin.
 TERMS,
   Defecation; is the removal from the body of indigestible substances, ie. passage of faecal matter through anus. Faecal matter is not true excretory product because it is not produced by metabolism.
   Secretion; is the production by metabolism of useful substances like enzymes and hormones.
Excretory Organs.
1.      Kidneys: They remove nitrogenous (urea and ammonia) compounds from the blood and eliminate excess water and salt.
2.      Liver: excretes bile pigments derived from   the decomposition of haemoglobin and urea.
3.      Lungs: Excrete carbon dioxide and water vapour.
4.      Skin: for water, mineral salts and trace of urea excretion.
Importance of excretion;
-It is necessary because if the wastes accumulates in the body, they will poison the body and kill the organism
-Provides a balance of chemicals in the body for its proper functioning
URINARY SYSTEM
The urinary system is a system concerned with production, storage and removed of urine.
-In human it is made up of the two kidneys. ureters, the bladder, the urethra, and the sphincter muscles 

Draw a neat labelled diagram of the human excretor toppr.com
Fig.The structure of urinary system

Each kidney  is a solid structure lying on the body wall at the back of the abdominal cavity
It is red-brown in colour and enclosed i the a thin membrane
There are two blood vessel connected to the kidney.Renal artery and renal vein

 i.Renal artery supplies blood to the kidney

  ii. Renal vein takes blood away from the kidney

Ureter is the tube which run from each kidney to the bladder. its function is to passes urine from the kidney to bladder for temporary storage
Th urinary bladder is a spherical muscular sac that located within the pelvic cavity .-It store  urine temporary
At the base of the urinary bladder there is a sphincter muscle that keep the bladder from emptying until it  reaches certain level
The urethra release the urine outside of the body.The wall of urethra is composed of mucous membrane and fibrous muscles tissueIn babies sphincter muscle is controlled by a reflex action triggered off by nerve endings in the stretched walls of the bladder. After about two years or less the muscle can be controlled voluntarily 
STRUCTURE OF KIDNEY

2.73 | PMG Biology
Fig.The structure of kidney

The kidney is bean-shaped with a depression near the centre of one side where there is ureter.It surrounded by fibrous connective tissue.The kidney has three distinct regions, namely the Cortex,Medulla and pelvisThe cortex is the outer The medulla is middle of layer of the kidney red in colour, it consists of  loop of Henle and collecting ducts of the nephronPelvis is the region into which urine temporary accumulates before draining into the urinary bladder and it is folded to form projection called PyramidThe renal artery divides up into a great many arterioles and capillaries, each arteriole leads to glomerulus which is almost entirely surrounded by cup shaped Bowmans’s capsule. Glomeruli were discovered by Marcello Malpighi..Each kidney tubule emerges from the Bowmans’s Capsule and after a complicated series of coils and loops, it joins the wider collecting duct which collect urine from the kidney tubule (Nephron).

THE NEPHRON
Nephron is the functional unit of the kidney.
- The kidney contains millions of nephron which lie partly in Cortex and in the medulla
PART OF NEPHRON
Each nephron consist of a long tubule closed at one end and open at the other

Draw a diagram of a nephron, and explain its struc toppr.com
Fig. the structure of nephron

1.Glomerulus.
This is fine inter-twined network of blood capillaries enclosed by Bowman's capsule
-It receives blood from an afferent arterioles a branch of renal artery.
-The blood is taken away from glomerulus by Efferent vessel towards renal vein.

2.Renal tubule
The renal tubuleis divided into five region
i Bownwn,scapsule.-The expended,cup-shaped part closed end of t the glomerulus
ii.Proximal convulated tubule
-The coiled part of the tubule next to the Bowman's capsule-it lie in the cortex
-i I t is highly coiled tube that extends to descending loop of Henle
iii.Loop of Henle
-The portionthat extends from the proximal comvulated tubule and dips into the medulla and it bend back into the cortex to for U-shape of loop.
-Ti made up of ascending and descending parts
iv.Distal convulated tubule
-The coiled part next to the  open end of the tubule which joins with a collecting duct.
v.Collecting duct.
This is the tube through which several other tubules empty their content.
-The collecting ducts lead to the pelvis of he kidney
ADAPTIVE FEATURES OF URINARY SYSTEM
The presence of numerous of glomeruli- Increase the ultrafiltration.
The different size of renal artery and renal vein..-renal vien is narrower than renal arery in order to slow down movement of blood out of glomerulus which inturn increase osmotic pressure.
The epithelial nature of the Bowman;s capsule-increases the movement of filtrate into the kidney tubule.Capillaries in the kidney tubule are more coiled and provide large surface area for reabsorptionThe kidney tubules has convulated structure that increase reabsoption of important minerals back into circulatory systemThe urinary bladder has sphincter muscles that when relaxed allow movement of urine to the outside.

THE PROCESS OF URINE FORMATION 

urine involves three steps, which all occur intthe nephrons of kidney. Filtration,reabsoption and secretion.

1.Filtration: Blood from the renal artery enters the glomerulus through narrow capillaries. The smaller molecules of the blood are forced under pressure out of the capillaries into the Bowmans’s capsule. Capillary membrane and capsule’s membrane act as a filter. Thus only plasma and tiny molecules like glucose, minerals, vitamins, amino acids, waste products and water  pass into the capsule and large molecules such as protein blood cell retained in the blood. Thes filtated are now called the glomerulus filtrate. Glomerulus and Bowmans’s capsule are called together as the malphigian Body.

 2.Reabsorption occurs as glomerulus filtrate passes out of the Bowmans’s capsule and down the kidney tubules towards the collecting ducts. All along this route, cells in the kidney tubule’s walls extract back useful substances from glomerulus filtrate so that by the time In the proximal convulated tubule all the glucose, amino acid. and some water and mineral are reabsorbed through the process of Active transport.it reaches the collecting ducts a liquid called urine has been formed. Urine contains urea and other waste excretory substances.

3. Secretion.takes place in the distal convulated tubules ,where by substances of high molecular weight including drugs and toxin are secreted into the tubule from the blood.The resulting fluid is called urine
-The urine is passes to collecting duct and finally into the bladder and where it stored temporarily before exit.-
  
         Components of urine
Content of urine
%
Water
95
Urea
2
Uric acid
0.03
Creatinine
0.1
Salts
1.4
Ammonia
0.04

The Liver.
The liver is a large, reddish-brown in colour owing to the large number of blood vessels it contains. It lies just below the diaphragm. It has two lobes, and gall bladder is placed between the lobes. The liver is the largest gland in our body. It is an enormous chemical factory which makes and release into the body many useful substances. As chemical factory, it needs a large supply of raw materials. The liver obtain its supplies from blood in Hepatic Portal vein, which brings all the digested food absorbed by the intestine.
    The liver regulates the amount of food which reaches the blood and tissue fluid. It does this by absorbing and storing food which it receives, and then releasing it into the circulatory system at a rate which depends upon the body’s current needs.
Structure of the Liver.




-Has many capillaries which gives it reddish-brown colour.
-Has two lobes, and gall bladder is between the two lobes.
-Is made up of small groups of cells called lobules. Each lobule is composed of great number of liver cells, between which are small blood vessel and very small bile ducts.
-The blood vessels: Hepatic artery- brings oxygenated blood.
   i.Hepatic portal vein- brings blood rich in digested food from the alimentary canal for control.
 ii. Hepatic vein. Carries away the deoxygenated blood.
Functions of the Liver.
1. Regulation of blood sugar: Excess glucose is converted into glycogen and fat under the influence of insulin. In case of decrease of blood glucose; the stored glycogen and fat are converted into glucose ready for respiration.
2. Deamination; Protein is digested into amino acids. Deamination is the removal of amino group from an amino acid, ie. changing Amino group (NH2) which would form poisonous Amonia (NH3) into less poisonous urea to be excreted through the kidney.
3. Detoxification; Is the process whereby harmful (poisonous) compounds (Drugs)  are converted to less  toxic compounds in the liver, which are then excreted through urine.
4. Manufacture of plasma protein- plasma proteins like prothrombin and fibrinogen (for blood clotting) are manufactured in the liver from the synthesise of amino acids.
5. Storage of minerals and vitamins such as A, B, D,E,K,B12 for red cells in the bone marrow.
6. Storage of blood; it is highly vascularized, so able to hold large volume of blood.
7. Formation of Erythrocytes in the liver of the foetus. The liver also breaks down the old erythrocytes.
8. Regulation of body heat.
9. Storage of iron: iron from the haemoglobin which comes  from the decomposition (breaking) of red blood cells is stored in the liver.
10. Formation of bile; when red blood cells break down, the green and yellow pigments are formed. These pigments are removed from the blood by the liver and excreted in the bile. Bile is stored in the gall bladder and is used for emulsifying fats.
The Skin.
 The skin is the largest organ of the body. Is continuous layer of tissue over the surface of the body.
Skin structure.
Skin consists of two main layers-outer-skin called epidermis.
                                                    -Inner skin called dermis.
A.     Epidermis.
1. The cornified layer: the horny layer; Is the outmost layer which consists of dead cells that form a tough outer coat. The cells are continually worn away and replaced from beneath. It may become very thick on the palms of the hand (when used for heavy works) and soles of feet. It contains keratin. The layer offers resistance from damage, bacteria, and from drying up.
2. The granular layer: contains living cells; towards the outside it gives way gradually to the cornified layer.
3. The malphigian layer. Contains living cells that divide actively to give rise to the upper layers of the skin. They contain pigments called melanin which gives colour to the skin and act as a screen against ultraviolet radiations/rays that can cause cancer.
Dermis:
   The dermis is a thicker layer of connective tissue with many elastic fibres in it. It contains sweat glands, receptor cells, blood vessels, lymphatic vessels, adipose tissue, hair follicles and sebaceous glands.
1. Blood capillaries: supply skin with the necessary food and oxygen and remove its excretory products. Sweat glands and hair follicles have net work of capillaries.
-capillaries beneath the epidermis play an important role in the temperature control.
2. Sweat glands: they are in deeper layers of the inner skin. Sweat gland is a coiled tube of one cell thick. It opens at the surface of the skin through sweat–pore. Sweat gland is surrounded by network of blood capillaries from which it extracts water containing waste substances. It absorbs excess water, mineral salts, traces of urea and lactic acid from blood vessels. It functions when the body temperature rises above the normal by between 0.2C to 0.5C.
3. Receptor cells: found within the dermis are able to detect different stimuli such as cold, heat, pressure, touch and pain.
4. Hair follicles: originate from the epidermis. Their bases are surrounded  by malphigian  and glanular layers. These are deep pit like where hair lies. Hair is made up of dead cells containing keratin. Hair root is embedded in the follicle.
  -The erector hair (pili) muscle is attached to the hair follicle and to the epidermis on the other end. The hair raise and lowers as muscle contracts and relaxes respectively.
  -The granular and malpighian  cells multiply and build up a hair inside the follicle. The constant adding of the new cells to the base of the hair causes it to grow.
5. Sebaceous gland: it produces oily sebum which keeps the epidermis supple (not crack), makes hair water proof, reduces tendency of skin becoming too dry after evaporation.
-Also has antiseptic substances which protects the skin against micro organisms.
6. Sub-cutaneous fat; is the layer beneath the dermis containing fat cells, ie. adipose tissue where fat is stored. The fat insulate the body against heat loss. In the presence of sunlight the layer also manufactures vitamin D.
Functions Of The Skin.
1. Against desiccation- prevents loss of water from the body by evaporation.
2. Protects body against entry of micro organism and damage due to friction.
3. Excretion of salts, excess water, traces of urea, lactic acid and carbon dioxide.
4. Regulation of body temperature.
5.      Prevention against  ultra violet rays penetrating the body through melanin pigment.
6.      Reception of stimulus, ie. cold, heat, pain, touch and pressure.
7.      Synthesis of vitamin D.
8.      Stores fats in the adipose tissue.

COMMON COMPLICATIONS AND DISORDERS OF THE EXCRETORY SYSTEM
I.Glomerulonephritis
Is a condition where the glomerular capillaries become inflamed and more permeable to protoein
-Proteins are excreted in the urine  a condition called proteinuria
-this result into the desease in the amount of protein in the blood plasma. a condition called hypoproteinaemia.
-The osmotic pressure of the blood lowers tissue fluid in the capillaries decrease and oedema occur
2. Kidney stones
-Form in the collecting ducts and pelvis of the kidney
-They contain uric acid, calcium oxalate, calcium phosphate or magnesium phosphate
-Stones containing calcium oxalate or phosphate
Results in the obstruction of urine flow or excess the certain chemicals in the blood stream

3.Cystitis
Is inflammation of the bladder caused by infection
 It caused by bacterial infection of bladder, usually the urethra
symptoms.
 - Frequent painful urination and cloudy urine
-Fever, blood in the urine if bacterial is passed to kidney.
Treatment.
-drinking a plenty of water that can relieve symptom and speed up recovery

4.Kidney failure.
Is the condition where one or both kidney cease to function

It is only treated by Dialysis or  kidney  transplant.
-Dialysis the patient's blood is linked  to a kidney machine
Excretion in plants.
Plants carry out metabolic processes like respiration and photosynthesis. The main waste products are water and oxygen in day time (photosynthesis) and carbon dioxide at night (respiration).
-  Other by-products from the metabolism of carbohydrates like resins and gums are stored in dead tissue of plants such as xylem.
Plants do not need special excretory organs because excretion is not a serious problem as it does in animals.
Why excretion is not a serious problem in plants:
-  The rate of catabolism is slow hence waste accumulates slowly.
-  Green plants can use much of their waste products, e.g. oxygen from photosynthesis can be used for respiration and the Carbon dioxide from respiration can be used for photosynthesis.
-  Nitrogenous compounds produced as waste can be used by plants in the synthesis of new
Proteins. (Nitrogenous wastes are dangerous in animals.)

Methods of excretion in plants.
-  Diffusion: for waste in gaseous form that is oxygen and carbon dioxide.
-  Transpiration: water containing by dissolved carbon dioxide and oxygen are excreted through transpiration.
-  Guttation: excretion of water and dissolved mineral salts, (through hydathodes)
-  Exudation: release of fluids at slow rate, e.g. gums, mucilage, resins, latex, rubber, calcium pectale and oxalates.
-  Deposition: Resins, tannins, caffeine, nicotine, quinine, morphine, khat, pyrithrin and papain are deposited in the xylem, bark, seeds, fruits, flowers and leaves of the plants. The depositions do not affect the metabolic activities. When these structures (leaves, flower, fruits, seeds, and bark) aged, they drop and there by releasing waste products.

Economic importance of plants’ Excretion.
Most of the excretory products are useful.
(i)   Anthocyanin: give colour to petals and leaves, e.g. red, purple and blue.
-These colours –are of great aesthetic value
-Used to make dyes.
-  To test PH of chemical solution.

(ii) Tannins: deposited in dead tissues that is wood and bark of acacia, conifers and mangroves.
Used in: preservative, treatment of leather; colour of tea.

Manufacture of ink; cosmetics, e.g. henna for nails, feet and hair
.
(iii) Latex: milky substance from rubber tree to make rubber.

(iv) Gumsproduced by Arabic and ghath and carob, used in: -thicken food and creams.
-  Manufacture of chewing gum e.g. sapadilla gum is used.

-  Agar from algae as medium to culture micro-organisms.
-  Some gums are edible.
(v) Alkaloids: produced in many forms and stored in different organs.
(a) Quinine: from bark of cinchona tree. Used in,
-Treatment for malaria.
-  -as stimulant in drinks.
(b) Cannabis: stored in flowers, fruit and leaves of Indian hemp(cannabis sativa)
-manufacture of drugs and painkillers.
-  - induce hallucinations.
(c) Cocaine: from leaves of cacao plants.
-As local anaesthetic.
-  effect like hallucination and convulsion
· is addictive when taken in large amounts and leads to heart ailments.
(d)Nicotine: in leaves of tobacco plant.
-  manufacture of insecticides
-  manufacture of narcotic drugs – makes one to relax or sleep
· Tar from tobacco is poisonous- can cause lung cancer.
(e) Caffeine: in coffee beans and tea leaves.
-Mild stimulant and refreshes.
-Reduce fatigue that is increases mental activity.
(f)  Morphine: from poppy plant.
-Make narcotic drugs.
- Pain killer and muscle relaxant.
(g) Papain: from papaw fruits.
-as meat tenderiser.
(h) Colchicine:
-Brings about mutation in genetic materials thus it is useful in plant breeding.
(i)   Khat (miraa/bhang): in leaves and twigs of tree.
-Stimulant.
(j)   Pyrithrim from pyrethrum flowers.
-Used in making insecticides.
(k) Alkaloids: in Irish potatoes when exposed to direct sunlight it turns tuber green.
-  They are bitter and poisonous in large quantity.
-  Protects tubers exposed on the ground from being fed on.